Post-doc position available and graduate students are welcome!
We are studying the developmental mechanisms of the brain using the fly visual center as a model.
Our lab has two names "Mathematical Neuroscience Unit" and "Lab. of Developmental Neurobiology".
The two different researches are on going in our lab.

<Developmental Neurobiology>
The fly visual center shares many important features with mammalian brains: production of wide variety of neurons in accord with order of neuron production and formation of layer and columnar structures accompanying neuronal migrations. Additionally, powerful molecular genetic tools of fly allow us high-resolution genetic manipulations. Using the fly visual system as a model, conserved mechanisms that govern formation of functional neuronal circuits are studied in our lab. Additionally, we use an apparatus called 'insect arena' to examine the functions of neural circuits in the fly visual center.

<Mathematical Neuroscience>
The interdiciplinary researches between biology and mathematics are essential for the further progress of the life sciences. Nevertheless, it is still very difficult to perform a true interdiciplinary research by mutulally combining biological experiments and numerical simulations. Based on the knowledges obtained from the above developmental neurobiology researches, we formulate mathematical models based on the real phenomena. Additionally, we confirm the validity of the models and the predictions from the models by in vivo experiments. We thus perform the true interdiciplinary researches of mathematical neuroscience in a lab. We also study mathematical modelings of stem cell biology by corraborating with other research groups.

Thus, it is the unique property of our lab that we focus on both developmental neurobiology and mathematical neuroscience at the same time.

If you are interested in either of the developmetal neurobiology research or mathematical neuroscience research,
feel free to contact me.

<News>
2022.5.24
Japanese Developmental Biology Conference will be held in Kanazawa city from 5/31 to 6/3

2022.4.7
Our paper was published in Current Biology
Hayashi, T., Tomomizu, T., Sushida, T., Akiyama, M., Ei, S-.I., and Sato, M.
Tiling mechanisms of the Drosophila compound eye through geometrical tessellation.
Current Biology 32, 2101-2109 (2022).

2021.6.6
Introduction to our recent researches were updated
(Spatio-tempral regulation of Nocth, Lineage-dependent repulsion and column formation, Polarity and arrangement of the columns)

2021.3.16
Our paper was accepted by Nature Communications
Wang, M., Han, X., Liu, C., Takayama, R., Yasugi, T., Ei, S., Nagayama, M., Tanaka, Y. and Sato, M.
Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain.
Nature Communications 12, 2083 (2021).

2021.1.8
A book for learning mathematical biology was published (Japanese).
A Practical Introduction to Mathematical Life Sciences, Corona publishing (2021).

2020.10.28
Our paper was published in Cell Reports (selected for the cover image)
Cell Reports 33, 108305(2020).

2020.8.14
Our paper was published in Nature Communications
Nature Communications 11, 4067 (2020).

2019.9.26
Our PhD student, Olena Trush, received her PhD and the president award (Photo).

2019.6.7
The Research and Photo pages were updated.

2019.5.15
Our paper was accepted by Journal of Neuroscience
Olena Trush, Chuyan Liu, Xujun Han, Yasuhiro Nakai, Rie Takayama, Hideki Murakawa, Jose A. Carrillo, Hiroki Takechi, Satoko Hakeda-Suzuki, Takashi Suzuki and Makoto Sato
N-cadherin orchestrates self-organization of neurons within a columnar unit in the Drosophila medulla
 Journal of Neuroscience 39, 5861-5880 (2019).
 

2018.9.27
Our paper was published in iScience
 iScience 8, 148-160 (2018.

2018.8.25
Our paper was accepted by iScience.
Takumi Suzuki, Chuyan Liu, Satoru Kato, Kohei Nishimura, Hiroki Takechi, Tetsuo Yasugi, Rie Takayama, Satoko Hakeda-Suzuki, Takashi Suzuki and Makoto Sato
Netrin signaling defines the regional border in the Drosophila visual center

2018.8.22
Our paper was published in Scientific Reports
 Scientific Reports 8, 12484 (2018).

2017.9.25
Our paper was published in Developmental Biology
 Developmental Biology 431,101-110 (2017).

2016.11.24
Please attend the syposium "Mathematical Biology of the Stem Cells and Cancer"

2016.10.7
Please attend "The Model Organism Conference at Kanazawa"

2016.8.18
Our paper was published in Proceedings of the National Academy of Sciences
 PNAS 113, E5153-E5162 (2016).

2016.7.7
Our paper was accepted by Proceedings of the National Academy of Sciences.
Sato, M., Yasugi, T., Minami, Y., Miura, T. and Nagayama, M.
Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion.

2016.6.15.
Our paper was published in Journal of Neuroscience
 Journal of Neuroscience 36, 6503-6513 (2016).

2016.5.10.
Our paper was accepted by Journal of Neuroscience
Suzuki, T., Trush, O., Yasugi, T., Takayama, R. and Sato, M.
Wnt signaling specifies antero-posterior progenitor zone identity in the Drosophila visual center.

2016.4.8.
Our paper was published in Cell Reports
  Cell Reports 15, 1-11 (2016).

2016.3.10.
Our paper in collaboration with RIKEN CDB was published in Cell Reports
  Cell Reports 11, 2718-2732 (2016).

2015.12.6.
Our paper was published in Developmental Biology
  Developmental Biology 409, 343-353 (2016).

2015.12.4.
Our paper was accepted by Developmental Biology
Suzuki, T., Takayama, R. and Sato, M.
eyeless/Pax6 Controls the Production of Glial Cells in the Visual Center of Drosophila melanogaster.

2015.2.10.
Makoto Sato was assigned to the Research Professor of Kanazawa University.

2014.10.1.
Makoto Sato joined to the research group of CREST, mathematical modeling 'Mathematical modeling and theoretical study on the spatiotemporal pattering of biological phenomena'.

2013.6.12.
Photo Album was updated

2014.6.4-6.
Our laboratory organized the 11th Drosophila Research Conference (JDRC11).

2013.6.12.
Our papers are now available from Developmental Biology
  Developmental Biology 380 (2013) 1-11.
  Developmental Biology 380 (2013) 12-24.
  Developmental Biology 377 (2013) 90-99.

2013.5.4.
Our paper was accepted by Developmental Biology
Suzuki, T., Kaido, M., Takayama, R. and Sato, M.
A temporal mechanism that produces neuronal diversity in the Drosophila visual center.

2013.4.10.
Our review article was accepted by Developmental Biology
Sato, M., Suzuki, T. and Nakai, T.
Waves of differentiation in the fly visual system.

2013.2.17.
Our paper was accepted by Developmental Biology
Hasegawa, E., Kaido, M., Takayama, R. and Sato, M.
Brain-specific-homeobox is required for the specification of neuronal types in the Drosophila optic lobe.

2012.4.9.
Makoto Sato received the Young Scientists' Prize, the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (link)

2012.4.1.
Affiliation of Sato lab changed to Brain/Liver Interface Medicina Research Center, Graduate School of Medical Sciences, Kanazawa University
Lab name was changed to "Laboratory of Developmental Neurobiology"
Makoto Sato was promoted to Professor
A new post-doc, Yasuhiro Nakai, joined our lab

2012.3.7-11.
Takumi Suzuki presented a poster at The 53rd Annual Drosophila Research Conference

2011.10.3-7.
Eri Hasegawa presented a poster at Cold Spring Harbor Laboratory Meeting on Neurobiology of Drosophila

2011.4.1.
A new post-doc, Takumi Suzuki, joined our lab

2011.2.16.
Makoto Sato became a member of the Editorial Board of Developmental Biology

2011.2.8.
Our paper was published online
  Development (2011) 138, 983-993 (Open Acess PDF file)
  Featured Article: 'Eyeing up neuronal circuits'

2010.12.1.
Our paper was accepted by Development (2010.12.1)
  Hasegawa, E., Kitada, Y., Kaido, M., Takayama, R., Awasaki, T., Tabata, T. and Sato, M.
  Concentric zones, cell migration and neuronal circuits in the Drosophila visual center.

2010.10.1.
Makoto Sato became a PRESTO researcher in the field of the neural networks